Lack of permanent nigrostriatal dopamine deficit following 6-hydroxydopamine injection into the rat striatum. Short communication

Autor:	J, Opacka-Juffry, S, Ashworth, A M, Sullivan, R B, Banati, S B, Blunt
Rok vydání:	1996
Předmět:	Male Neurons Time Factors Microinjections Rotation Tyrosine 3-Monooxygenase Dopamine Neurotoxins Motor Activity Corpus Striatum Rats Rats Sprague-Dawley Substantia Nigra Radioligand Assay Animals Oxidopamine Tomography Emission-Computed
Zdroj:	Journal of neural transmission (Vienna, Austria : 1996). 103(12)
ISSN:	0300-9564
Popis:	The lesion caused by a single 6-hydroxydopamine injection into rat striatum was evaluated. In vivo positron emission tomography using a dopamine reuptake tracer revealed no consistent reduction in striatal dopamine transporter. Amphetamine rotation test was negative up to 18 weeks. A 21% reduction in striatal dopamine seen at 11 weeks was not detectable at 18 weeks. Tyrosine hydroxylase-positive neurone counts showed no decline in substantia nigra. Our results suggest that this lesion may be subject to compensation and therefore should be used with caution in studies on neuroprotective treatments of Parkinson' disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d3227fd90516bf9f124635b0e973066a https://pubmed.ncbi.nlm.nih.gov/9029409 Zobrazit plný text záznamu Full text from SpringerLink