Radiotherapeutic treatment of brain metastases in patients with gynecologic malignancies: A nationwide analysis

Autor: Rodney E, Wegner, John, Bergin, Linda, Xu, Alexander, Yu, Zachary D, Horne, Thomas, Krivak, Stephen M, Karlovits
Rok vydání: 2020
Předmět:
Zdroj: J Radiosurg SBRT
ISSN: 2156-4647
Popis: Objectives: Brain metastases are a rare finding in patients with primary gynecologic malignancies having a poor outcome despite treatment. We sought to use the National Cancer Database (NCDB) to characterize the incidence of brain metastases and types of treatment administered. Methods: We queried the NCDB from 2010-16 for patients with endometrial, cervical, and ovarian primaries with brain metastases at diagnosis treated with radiation—whole brain radiation (WBRT) or stereotactic radiosurgery (SRS). We tabulated baseline characteristics and performed a multivariable logistic regression to identify predictors of SRS. Multivariable Cox regression was used to identify predictors of death. Propensity matching was done to account for indication bias. Results: We identified 765 patients meeting above criteria, representing
Databáze: OpenAIRE