[Serologic diagnostics of Legionella infection]
| Autor: | G L, Karbyshev, A N, Terent'ev, L M, Verkina, I R, Simonova, A P, Kochetkova, A N, Narkevich, L K, Lysova, L V, Larionova |
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| Rok vydání: | 2008 |
| Předmět: |
Lipopolysaccharides
Agglutination Antigens Bacterial Bacteriological Techniques Legionellosis Polymers Immune Sera Immunoglobulins Legionella Antibodies Bacterial Sensitivity and Specificity Microspheres Immunoenzyme Techniques Antibody Specificity Animals Humans Rabbits Reagent Kits Diagnostic Bacterial Outer Membrane Proteins |
| Zdroj: | Zhurnal mikrobiologii, epidemiologii i immunobiologii. (2) |
| ISSN: | 0372-9311 |
| Popis: | Technical approaches to construction of preparations for serologic diagnostics of Legionella infection were presented in the article; antigenic- and immunoglobulin-based diagnostic kits with known characteristics were developed. Immunogenic properties of protein and lypopolysaccharide antigens, which have diagnostic value, were studied; similarity of protein antigens from 7 serogroups of L. pneumophila was demonstrated. Soluble antigen with known composition was obtained and used for the development of antigen-based polymeric kit for diagnostics of Legionella infection. On the basis of hyperimmune sera, immunoglobulin-based polymeric diagnostic kit and array of coagglutinating diagnostic kits for the mentioned 7 serogroups were developed. Antigen-based polymeric diagnostic kit was recommended for licensure. |
| Databáze: | OpenAIRE |
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