Lipid and lipoprotein responses to oral combined hormone replacement therapy in normolipemic obese women with controlled type 2 diabetes mellitus

Autor:	S H, Lilley, J M, Spivey, S, Vadlamudi, J, Otvos, D M, Cummings, H, Barakat
Rok vydání:	2001
Předmět:	Glycated Hemoglobin Diabetes Mellitus Type 2 Lipoproteins Estrogen Replacement Therapy Administration Oral Humans Female Obesity Middle Aged Particle Size Lipids Aged
Zdroj:	Journal of clinical pharmacology. 38(12)
ISSN:	0091-2700
Popis:	This study investigated the effects of oral combined hormone replacement therapy (OCHRT) on lipid concentrations and subpopulation distribution of lipoproteins in nine postmenopausal women with type 2 diabetes mellitus and moderate glycemic control. After 16 weeks of continuous daily therapy of conjugated estrogens 0.625 mg and medroxyprogesterone 2.5 mg, the mean concentration of high-density lipoprotein (HDL) cholesterol showed a statistically significant increase of 16.7%, predominantly in the HDL2 subfraction. No statistically significant changes in mean concentrations of total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, very low-density lipoprotein (VLDL) triglycerides, apolipoprotein A1, or apolipoprotein B were evident. Likewise, no changes were found in the average diameter of VLDL, LDL, or HDL particles; triglyceride concentrations of VLDL subfractions; cholesterol concentrations of LDL subfractions; or chemical composition of plasma LDL. These findings lend further support to the use of OCHRT in postmenopausal women with diabetes to decrease their risk for coronary artery disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d2c66844dbce49b6845768b1f25fa19d https://pubmed.ncbi.nlm.nih.gov/11301562 Zobrazit plný text záznamu Plný text