| Autor: |
Veysel, Sal, Ilker, Kahramanoglu, Tugan, Bese, Fuat, Demirkiran, Nigar, Sofiyeva, Zeynep, Soyman, Sinem, Durmus, Remisa, Gelisgen, Macit, Arvas, Hafize, Uzun |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
The journal of obstetrics and gynaecology research. 43(2) |
| ISSN: |
1447-0756 |
| Popis: |
The aim of the present study was to evaluate the usefulness of nestin as a discriminative marker between benign and malignant ovarian tumors.During the 1 year from January 2015 through December 2015, a nonconsecutive series of 80 patients (40 malignant, 40 benign) who underwent surgery for an adnexal mass were enrolled in the study. Intraoperative frozen section evaluation was performed if there was a suspicion in diagnosis. Statistical analyses were performed using spss ver. 16.0, while clinicopathological variables, including the categorical data, were analyzed using the χPreoperative serum carbohydrate antigen (CA)-125, CA-15-3, and nestin levels were significantly higher in the malignant group compared to patients with benign ovarian tumors (P0.001, respectively). Serum nestin levels did not differ significantly on the basis of histologic subtypes. Serum nestin levels had specificity of 89.7%, which demonstrates nestin's sufficiency to distinguish benign from malignant epithelial ovarian tumors. The positive likelihood ratio of nestin was found to be superior to that of CA-125 and CA-15-3.The results obtained from our study suggest that measurement of nestin level, alongside physical examination, transvaginal ultrasound, and serum CA-125 and CA-15-3 levels, can help differentiate benign ovarian tumors from malignant epithelial ovarian tumors. The findings of our study need to be supported with additional studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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