[Protection of mice by carbamates cholinesterase inhibitors against poisoning by armin and its dependence on certain physico-chemical indicators]

Autor:	V B, Prozorovskiĭ, L V, Pavlova, I M, Suslova, A V, Sazonova, A V, Kokushkina
Rok vydání:	2000
Předmět:	Male Mice Structure-Activity Relationship Pyridines Poisoning Animals Humans Carbamates Cholinesterase Inhibitors Armin Pyridostigmine Bromide
Zdroj:	Voprosy meditsinskoi khimii. 45(6)
ISSN:	0042-8809
Popis:	A series of aminostigmin derivatives with various substituents at nitrogen in the second position of the pyridine ring, has been tested. The efficacy of preventing the death of mice poisoned by armine in five of the seven substances correlates with the constant of the rate of carbamylation of acetylcholinesterase in the in vitro experiments and with the hydrophobic nature. It is suggested that the phenomenon of protection of animals against the toxic effect of organophosphorous compounds involves the "leaving portion" of the molecule of carbamates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d2b5822f3d433c8ec38221300713dcdd https://pubmed.ncbi.nlm.nih.gov/10761219 Zobrazit plný text záznamu