| Autor: |
M, Bonnet, F, Mishellany, J, Papon, A, Cayre, F, Penault-Llorca, J C, Madelmont, E, Miot-Noirault, J M, Chezal, N, Moins |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Pigment cellmelanoma research. 23(5) |
| ISSN: |
1755-148X |
| Popis: |
Targeted internal radionuclide therapy (TRT) could be an efficient, specific way to treat disseminated melanoma. Based on a previous pharmacomodulation study, we selected a quinoxaline-derived molecule (ICF01012) for its melanin specificity and kinetic properties suitable for TRT. Here, we determined the efficacy of [(131)I]ICF01012 radiotherapy in vitro and in vivo in relation to melanogenesis using human melanoma models. [(125)I]ICF01012 uptake was first assessed in relation to melanin content. We found that melanin distribution in different models was representative of pathology seen in human tumours: melanin content was high in the extracellular space of SKMel3 tumours, and accumulated primarily in melanophages in M4Beu tumours. Targeted [(131)I]ICF01012 radiotherapy had a strong anti-tumoural efficacy in pigmented versus unpigmented tumours, regardless of target distribution and content. This study supports the use of melanin targeting with (131)I-labelled iodoquinoxaline for effective treatment of melanoma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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