| Autor: |
Hiroyuki, Nakamura, Syuji, Oishi, Hisanaga, Yagyu, Takahiro, Morisako, Koji, Kishi, Fumihiro, Tsuchida, Hideki, Adachi, Gen, Sarashina, Akihiko, Sudoh, Toshio, Hashimoto, Takeshi, Matsuoka |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 40(5) |
| ISSN: |
1343-3490 |
| Popis: |
NTx and I CTP, a metabolite of type I collagen, were compared as to their usefulness as indicators of bone metastasis in lung cancer. The NTx level was significantly higher in lung cancer patients with bone metastasis (107.9 +/- 56.1 nM BCE/mM) than in those without it (p0.0001), as was the I CTP level (10.0 +/- 6.5 ng/ml; p0.0001). The Z scores of NTx and I CTP were 2.37 and 2.04, respectively, indicating that NTx is superior to I CTP in sensitivity to bone metastasis because of its higher Z score and its higher area under the ROC curve. The cutoff values of these markers were set to produce the highest accuracy/sensitivity rates and to make possible the highest diagnostic efficiency, and then the odds ratios at these cutoff values were calculated. The odds ratios of NTx and I CTP at cutoff values for the highest accuracy were 66.3 and 12.6, respectively; those offering the highest diagnostic efficiency were 46.5 and 10.0, respectively. These results indicated that NTx offers better prediction of bone metastasis in lung cancer than does I CTP. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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