In vivo brain endocannabinoid metabolism is related to hippocampus glutamate and structure - a multimodal imaging study with PET

Autor:	Jeremy J, Watts, Elisa, Guma, Sofia, Chavez, Rachel F, Tyndale, Ruth A, Ross, Sylvain, Houle, Alan A, Wilson, Mallar, Chakravarty, Pablo M, Rusjan, Romina, Mizrahi
Rok vydání:	2021
Předmět:	Male Polyunsaturated Alkamides Glutamine Proton Magnetic Resonance Spectroscopy Brain Glutamic Acid Arachidonic Acids Hippocampus Magnetic Resonance Imaging Multimodal Imaging Young Adult Positron-Emission Tomography Humans Female Endocannabinoids
Zdroj:	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 47(11)
ISSN:	1740-634X
Popis:	Dysregulation of hippocampus glutamatergic neurotransmission and reductions in hippocampal volume have been associated with psychiatric disorders. The endocannabinoid system modulates glutamate neurotransmission and brain development, including hippocampal remodeling. In humans, elevated levels of anandamide and lower activity of its catabolic enzyme fatty acid amide hydrolase (FAAH) are associated with schizophrenia diagnosis and psychotic symptom severity, respectively (Neuropsychopharmacol, 29(11), 2108-2114; Biol. Psychiatry 88 (9), 727-735). Although preclinical studies provide strong evidence linking anandamide and FAAH to hippocampus neurotransmission and structure, these relationships remain poorly understood in humans. We recruited young adults with and without psychotic disorders and measured FAAH activity, hippocampal glutamate and glutamine (Glx), and hippocampal volume using [
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d288843a218ab9ba70dd2966a97e101c https://pubmed.ncbi.nlm.nih.gov/35906490 Zobrazit plný text záznamu Full text from SpringerLink