Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury

Autor:	G S, Scott, L B, Jakeman, B T, Stokes, C, Szabó
Rok vydání:	1999
Předmět:	Adenosine Diphosphate Rats Sprague-Dawley Nitrates Spinal Cord Contusions Laminectomy Animals Tyrosine Female Poly(ADP-ribose) Polymerases Spinal Cord Injuries Rats
Zdroj:	Annals of neurology. 45(1)
ISSN:	0364-5134
Popis:	Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrotyrosine, an indicator of peroxynitrite generation, and poly (ADP) ribose, a marker of PARS activation, were selectively localized within tissues from spinal cord-injured rats. Our data implicate a role for peroxynitrite production and PARS activation in the development of spinal cord trauma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d25bb17d2e7539221e42bc4ab6c0bb9a https://pubmed.ncbi.nlm.nih.gov/9894885 Zobrazit plný text záznamu Plný text