Intractible cutaneous non-Hodgkin's lymphoma of the lower limb. Complete remission after sequential regional isolated hyperthermic perfusion and perfusion with 1-phenylalanine-mustard (melphalan, L-Pam)

Autor:	R F, Jansen, B N, van Geel, J, van der Zee, A, Hagenbeek, P C, Levendag
Rok vydání:	1989
Předmět:	Male Leg Skin Neoplasms Chemotherapy Cancer Regional Perfusion Lymphoma Non-Hodgkin Humans Hyperthermia Induced Middle Aged Combined Modality Therapy Melphalan
Zdroj:	Cancer. 64(2)
ISSN:	0008-543X
Popis:	A 61-year-old man with an intractible and progressively disabling cutaneous non-Hodgkin's lymphoma (NHL) in the lower limb was treated with sequential regional isolated perfusion at 10-day intervals. The first perfusion was hyperthermic (40.2-43.1 degrees C tumor-temperature); the second was at controlled normothermia with high-dose 1-phenylalanine mustard (melphalan, L-Pam; 11 mg/l perfused tissue). This treatment resulted in a complete remission in the perfused area of significant duration and has prevented amputation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d255e7e4f8752f5192d794dd9d30aee3 https://pubmed.ncbi.nlm.nih.gov/2736485 Zobrazit plný text záznamu Plný text