| Autor: |
Chun-Ji, Gao, Wan-Ming, DA, Bo-Long, Zhang, Xiao-Ping, Han, Yu, Jing, Hong-Hua, Li, Jian, Bo, Hai-Yan, Zhu, Hai-Jie, Jin, Xiao-Xiong, Wu, Quan-Xun, Wang, Su-Sia, Li, Wen-Rong, Huang, Li, Yu |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 14(1) |
| ISSN: |
1009-2137 |
| Popis: |
This study was aimed to explore feasibility and efficacy of unrelated donor peripheral blood stem cell transplantation (UD-PBSCT) in treatment of hematologic malignancies. Ten patients with hematologic malignancies underwent high resolution DNA based typing HLA-matched or 1 locus mismatched UD-PBSCT. Busulfan, cyclophosphamide, Ara-C, MeCCNU and antithymocyte globulin (ATG) were used for preconditioning regimen in all cases. All patients received mycophenolate mofetile, cyclosporin A and short-term methotrexate with CD25 antibody as the graft-versus-host disease (GVHD) prophylaxis. The results showed that rapid engraftment was observed in all cases who presented full donor chimerism at 28 days post transplantation by STR-PCR. The median time of neutrophil recovery0.5 x 10(9)/L, platelet recovery20 x 10(9)/L was 13, 17.5 days respectively after transplantation. The incidence of acute GVHD was 3 cases (one case with grade I was recovered from GVHD by himself, one case with grade III was cured, one case with grade VI was died). It is concluded that above-mentioned preconditioning regimen and GVHD prophylaxis are effective approaches for unrelated donor peripheral blood stem cell transplantation in hematopoietic malignancies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
