| Autor: |
M R, Cook, C, Graham, R, Kavet, R G, Stevens, S, Davis, L, Kheifets |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Journal of pineal research. 28(1) |
| ISSN: |
0742-3098 |
| Popis: |
We evaluated the feasibility of using morning urine samples in epidemiological studies aimed at clarifying the relationship between nocturnal melatonin levels and breast cancer risk. Initially, a laboratory-based study of 29 women (40- 70 yr old) was performed to examine the correlation between plasma melatonin levels in hourly nocturnal blood samples and both melatonin and its major enzymatic metabolite, 6-hydroxymelatonin-sulfate (6-OHMS) in morning urine samples. In a companion field study, morning urine samples were collected from 203 healthy women to assess similarities and differences in laboratory versus field measures. Taken together, our results indicate: 1) levels of melatonin and of creatinine-corrected 6-OHMS in the first morning void urine are strongly correlated with total nocturnal plasma melatonin output (P0.001) and also with peak nocturnal melatonin values (P0.001); 2) similar ranges for 6-OHMS were found in the laboratory and the field; and 3) neither menopausal status nor hormonal replacement therapy altered 6-OHMS values in morning void urine. The inclusion of morning urine samples in epidemiological studies of cancer could allow cost-effective, widespread testing of the role played by melatonin in human health and disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Plný text