| Autor: |
Michela, Panini, Francesco, Tozzi, Christoph T, Zimmer, Chris, Bass, Linda, Field, Valerio, Borzatta, Emanuele, Mazzoni, Graham, Moores |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Pest management science. 73(9) |
| ISSN: |
1526-4998 |
| Popis: |
Metabolic resistance is an important consideration in the whitefly Bemisia tabaci, where an esterase-based mechanism has been attributed to pyrethroid resistance and over-expression of the cytochrome P450, CYP6CM1, has been correlated to resistance to imidacloprid and other neonicotinoids.In vitro interactions between putative synergists and CYP6CM1, B and Q-type esterases were investigated, and structure-activity relationship analyses allowed the identification of chemical structures capable of acting as inhibitors of esterase and oxidase activities. Specifically, methylenedioxyphenyl (MDP) moieties with a polyether chain were preferable for optimum inhibition of B-type esterase, whilst corresponding dihydrobenzofuran structures were potent for the Q-esterase variation. Potent inhibition of CYP6CM1 resulted from structures which contained an alkynyl chain with a terminal methyl group.Synergist candidates could be considered for field control of B. tabaci, especially to abrogate neonicotinoid resistance. © 2017 Society of Chemical Industry. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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