[Continued complete remission of Merkel cell carcinoma with in-transit metastasis after treatment with isolated limb perfusion regional chemotherapy]
| Autor: | C, Grandpeix, S, Bonvalot, P, Petrow, S, Fraitag, N, Gounod, M F, Avril |
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| Jazyk: | francouzština |
| Rok vydání: | 2006 |
| Předmět: |
Leg
Sclerosis Skin Neoplasms Remission Induction Magnetic Resonance Imaging Carcinoma Merkel Cell Chemotherapy Cancer Regional Perfusion Humans Female Neoplasm Invasiveness Range of Motion Articular Antineoplastic Agents Alkylating Melphalan Pigmentation Disorders Ankle Joint Aged Follow-Up Studies Skin |
| Zdroj: | Annales de dermatologie et de venereologie. 133(8-9 Pt 1) |
| ISSN: | 0151-9638 |
| Popis: | Primitive cutaneous neuroendocrine carcinoma or Merkel cell carcinoma is a rare tumor. It may be large since diagnosis is frequently delayed. The usual treatment is extensive surgical removal and radiotherapy.A 69-year-old woman presented with a large Merkel cell carcinoma of the right leg. MRI showed a tumor invading the deep layers together with several satellite lesions. There was no regional nodal or visceral metastasis. Regional chemotherapy involving isolated limb perfusion with melphalan was performed in order to avoid amputation. Complete response was achieved a few months later and continues 5 and a half years later with minor sequelae comprising cutaneous sclerosis, pigmentation and mild ankle stiffness.Only five cases of Merkel cell carcinoma treated with isolated limb perfusion are reported in the literature: four of these involved local relapse and one was a primary tumor with regional lymph node involvement. Only one patient was still in complete remission 18 months after treatment. Isolated limb perfusion chemotherapy could thus be indicated in the treatment of advanced Merkel cell carcinoma of a limb in the absence of bone or regional lymph node involvement. |
| Databáze: | OpenAIRE |
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