[Detection of P-glycoprotein and glutathine S-transferase in mucoepidermoid carcinoma of salivary gland]
| Autor: | Jia, He, Da-zhang, Wang, Guang-yong, Zheng, Ge, Feng |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Adolescent Antibodies Monoclonal Middle Aged Salivary Gland Neoplasms Drug Resistance Multiple Salivary Glands Isoenzymes Glutathione S-Transferase pi Drug Resistance Neoplasm Humans Carcinoma Mucoepidermoid Female ATP Binding Cassette Transporter Subfamily B Member 1 Genes MDR Child Aged Glutathione Transferase |
| Zdroj: | Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology. 22(2) |
| ISSN: | 1000-1182 |
| Popis: | The aim of this study was to investigate the mechanism(MDR) of multidrug resistance(MDR) of mucoepidermoid carcinoma in salivary gland.40 cases of mucoepidermoid carcinoma in salivary gland were examined the MDR gene product P-glycoprotein using a monoclonal antibody JSB-1. And 10 of them were also investigated by detecting the expression of GST-pi. All the cases had not been accepted any therapy before the samples were collected.1. Positive expression of JSB-1 was observed in 27 of the 40 specimens. The positive expression was related not only with clinical stage, but also with differentiation degree. 2. The GST-pi positive expression was found in 9 of 10 cases. There was no significant different between the positive expression of JSB-1 and GST-pi.JSB-1 and GST-pi play an important role in MDR of mucoepidermoid carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|