Murine gammaherpesvirus-68 infection of mice: A new model for human cerebral Epstein-Barr virus infection

Autor:	Martin, Häusler, Bernd, Sellhaus, Simone, Scheithauer, Matthias, Engler, Evelyn, Alberg, Andreas, Teubner, Klaus, Ritter, Michael, Kleines
Rok vydání:	2005
Předmět:	Disease Models Animal Epstein-Barr Virus Infections Mice Gammaherpesvirinae DNA Viral Animals Brain Humans Herpesviridae Infections Immunohistochemistry Polymerase Chain Reaction Administration Intranasal
Zdroj:	Annals of neurology. 57(4)
ISSN:	0364-5134
Popis:	Epstein-Barr virus infection may cause severe neurological complications that are not mirrored by animal models. Here, we show that nasal inoculation of newborn BALB/c wild-type mice with MHV-68, a murine gammaherpesvirus, causes cerebral infection with inflammation in 50% of the animals. The inflammatory patterns are strikingly similar to those known from Epstein-Barr virus, including hydrocephalus, meningitis, cerebellitis, focal or diffuse encephalitis, and temporal lobe encephalitis. This offers a new powerful tool to study the virological and immunological characteristics of cerebral gammaherpesvirus infections.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d12a8e253f139187fc08b43cec89fa66 https://pubmed.ncbi.nlm.nih.gov/15786475 Zobrazit plný text záznamu Plný text