Combined evaluation of proliferation and apoptosis to calculate IC

Autor:	Yeliz, Ekici, Abdullah, Yilmaz, Umut Can, Kucuksezer, Sema Bilgic, Gazioglu, Zeynep Dogusan, Yamalioglu, Ali Osman, Gurol, Thomas, Linn, Feyza Nur, Tuncer
Rok vydání:	2021
Předmět:	Gene Expression Regulation Neoplastic Pancreatic Neoplasms Inhibitory Concentration 50 Lymphoid Enhancer-Binding Factor 1 Valproic Acid Tumor Cells Cultured Humans Anticonvulsants Apoptosis Wnt Signaling Pathway Carcinoma Pancreatic Ductal Cell Proliferation
Zdroj:	Medical oncology (Northwood, London, England). 38(9)
ISSN:	1559-131X
Popis:	Pancreatic ductal adenocarcinoma (PDAC) is among the most deadly cancers. Since most patients develop resistance to conventional treatments, new approaches are in urgency. Valproic acid (VPA) was shown to induce apoptosis and reduce proliferation in PANC-1 cells. Wnt signaling pathway is known to be involved in apoptosis and PDAC onset. However, VPA-induced apoptosis and its impact on Wnt signaling in PDACs are not linked, yet. We aimed to calculate IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d0f081abb07ec42293d9a9adfbc5bbf0 https://pubmed.ncbi.nlm.nih.gov/34357487 Zobrazit plný text záznamu Full text from SpringerLink