| Autor: |
Ayaka, Ozaki, Hitomi, Motomura, Shoma, Tamori, Chotaro, Onaga, Yuka, Nagashima, Maho, Kotori, Chika, Matsuda, Akari, Matsuda, Nanako, Mochizuki, Tsugumichi, Sato, Yasushi, Hara, Keiko, Sato, Yohei, Miyagi, Yoji, Nagashima, Takehisa, Hanawa, Yohsuke, Harada, Yuyun, Xiong, Kazunori, Sasaki, Shigeo, Ohno, Kazunori, Akimoto |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Anticancer research. 42(7) |
| ISSN: |
1791-7530 |
| Popis: |
p62 (also known as sequestosome 1) is involved in cancer progression, and high expression of p62 indicates poor clinical outcome in several cancer types. However, the association between p62 gene expression and cancer stem cells (CSCs) in breast cancer subtypes remains unclear.In the present study, genomic datasets of primary breast cancer (The Cancer Genome Atlas, n=593; and Molecular Taxonomy of Breast Cancer International Consortium, n=2,509) were downloaded. p62 Expression was then examined in normal and breast cancer tissues derived from the same patients. Kaplan-Meier and multivariate Cox regression analyses were employed to evaluate disease-specific survival. Next, the effect on cell viability and in vitro tumor-sphere formation of p62 knockdown using targeted small interfering RNA was assessed by using cells with high activity of aldehyde dehydrogenase 1 (ALDH1Patients with normal-like, luminal A or luminal B breast cancer with p62p62 is potentially a prognostic marker and therapeutic target for ALDH1-positive luminal B breast CSCs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
