| Autor: |
Annette, Pflugfelder, Xuan Ling Hilary, Yong, Kasturee, Jagirdar, Thomas K, Eigentler, H Peter, Soyer, Richard A, Sturm, Lukas, Flatz, David L, Duffy |
| Rok vydání: |
2022 |
| Zdroj: |
Cancers. 14(10) |
| ISSN: |
2072-6694 |
| Popis: |
Melanoma incidence rates are high among individuals with fair skin and multiple naevi. Established prognostic factors are tumour specific, and less is known about prognostic host factors. A total of 556 stage I to stage IV melanoma patients from Germany with phenotypic and disease-specific data were analysed; 64 of these patients died of melanoma after a median follow-up time of 8 years. Germline DNA was assessed by the HumanCoreExome BeadChip and data of 356,384 common polymorphisms distributed over all 23 chromosomes were used for a genome-wide analysis. A suggestive genome-wide significant association of the intronic allele rs7551288*A with diminished melanoma-specific survival was detected ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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