Correlation between serum calcium levels and dual-phase (99m)Tc-sestamibi parathyroid scintigraphy in primary hyperparathyroidism
| Autor: | D S, Mshelia, A N, Hatutale, N P, Mokgoro, M E, Nchabaleng, J R, Buscombe, M M, Sathekge |
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| Rok vydání: | 2011 |
| Předmět: |
Adenoma
Adult Male Technetium Tc 99m Sestamibi Adolescent Multimodal Imaging Parathyroid Glands South Africa Young Adult Predictive Value of Tests Humans Prospective Studies Aged Aged 80 and over Middle Aged Hyperparathyroidism Primary Up-Regulation Cross-Sectional Studies Parathyroid Neoplasms Parathyroid Hormone Positron-Emission Tomography Hypercalcemia Calcium Female Radiopharmaceuticals Tomography X-Ray Computed Biomarkers |
| Zdroj: | Clinical physiology and functional imaging. 32(1) |
| ISSN: | 1475-097X |
| Popis: | The goal of the study is to correlate serum calcium levels with the results of dual-phase (99m)Tc-sestamibi parathyroid scintigraphy to find the best cut-off level of the serum calcium that correlates with a positive presurgery.In 111 patients, serum calcium and plasma parathormone (PTH) levels were compared with the results of the (99m)Tc-MIBI scintigraphy and with this data determined the level of calcium above which the (99m)Tc-MIBI scintigraphy was likely to be positive and below which the study was likely to be negative.In total, 11 men (18%) and 50 women (82%) had a positive (99m)Tc-MIBI study. Overall 67% of those patients with a positive (99m)Tc-MIBI study had a PTH200 ng l(-1) compared to only 9% of those with a negative (99m)Tc-MIBI scintigraphy; however, for those with a positive study on an early (99m)Tc-MIBI scintigraphy, this rose to 85%. Overall a serum calcium of2·70 mmol l(-1) was found in 82% of patients with a positive (99m)Tc-MIBI study but only 14% of those with a negative (99m)Tc-MIBI study, this is rose to 97% of patients with a parathyroid adenoma identified on early images. It is also shown that patients whose serum total calcium2·51 mmol l(-1) rarely have positive (99m)Tc-MIBI scintigraphy.(99m)Tc-MIBI parathyroid scintigraphy is most likely to yield identification and localization of a parathyroid adenoma when both PTH and calcium are elevated; however, although there is no lower limit of PTH which can predict a negative study, we cannot recommend (99m)Tc-MIBI parathyroid scintigraphy if the serum calcium is2·51 mmol l(-1). |
| Databáze: | OpenAIRE |
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