| Autor: |
Irene, Lorrai, Chase, Shankula, Jorge Marquez, Gaytan, Tomoya, Kawamura, Paola, Maccioni, Claudia, Mugnaini, Federico, Corelli, Gian Luigi, Gessa, Pietro Paolo, Sanna, Giancarlo, Colombo |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Psychopharmacology. 239(1) |
| ISSN: |
1432-2072 |
| Popis: |
Binge drinking (BD) is a widespread drinkingpattern that may contribute to promote the development of alcohol use disorder (AUD). The comprehension of its neurobiological basis and the identification of molecules that may prevent BD are critical. Preclinical studies demonstrated that positive allosteric modulators (PAMs) of the GABAThe present study investigated whether the "anti-alcohol" properties of COR659 extend to binge-like drinking in rodents.COR659 was tested on the "drinking in the dark" (DID) paradigm in C57BL/6J mice and the 4-bottle "alcohol [10%, 20%, 30% (v/v)] versus water" choice regimen with limited and unpredictable access to alcohol in sP rats.Acute administration of non-sedative doses of COR659 (10, 20, and 40 mg/kg; i.p.) effectively and selectively suppressed the intake of intoxicating amounts of alcohol (2 g/kg) consumed by C57BL/6J mice and sP rats exposed to these binge-like drinking experimental procedures.The present data demonstrate the ability of COR659 to suppress binge-like drinking in rodents and strengthen the hypothesis that GABA |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink