| Autor: |
Tatiane Piedade, de Souza, Darlen Cardoso, de Carvalho, Alayde Viera, Wanderley, Sweny Marinho, Fernandes, Juliana Carla Gomes, Rodrigues, Amanda, Cohen-Paes, Marianne Rodrigues, Fernandes, Fernando Augusto Rodrigues, Mello Junior, Lucas Favacho, Pastana, Lui Wallacy Morikawa Souza, Vinagre, Artur Luiz da Costa, Silva, Paulo Pimentel, de Assumpção, Sidney, Santos, André Salim, Khayat, Ney Pereira Carneiro, Dos Santos |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Am J Transl Res |
| ISSN: |
1943-8141 |
| Popis: |
Acute Lymphoblastic Leukemia (ALL) is the most common type of cancer in children. Polymorphisms that alter the normal function of the microRNAs involved in the development of ALL have been widely investigated, although published data on these polymorphisms in admixed populations are scarce. We investigated the role of 10 polymorphisms in the microRNA and protein-coding genes of the microRNA synthesis complex in susceptibility to pediatric B-cell ALL. The study includes 100 pediatric ALL patients and 180 healthy individuals. The statistical analyses were run in SPSS v.25.0. In the case of the microRNA synthesizing genes, a significant pattern was found in only gene, that is, the rs3805500 polymorphism of DROSHA, in which the homozygous mutant (AA) genotype was associated with a threefold increase in the risk of developing ALL when compared to other genotypes (P=0.004, OR=2.913, CI=1.415-5.998). In the microRNA coding genes, the homozygous mutant rs3746444 genotype of the MIR499A gene was associated with a 17-fold increase in the risk of development of ALL (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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