Angiotensin II receptor blockade in Syrian hamster (T0-2) cardiomyopathy does not affect microscopic cardiac material properties: implications for mechanisms of tissue remodeling
| Autor: | G M, Lanza, M J, Scott, G, Davison, C S, Hall, D H, Christy, J G, Miller, S A, Wickline |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Receptors Angiotensin Mesocricetus Angiotensin II Myocardium Body Weight Imidazoles Tetrazoles Blood Pressure Heart Organ Size Cardiomyopathy Hypertrophic Receptor Angiotensin Type 2 Receptor Angiotensin Type 1 Angiotensin Receptor Antagonists Echocardiography Cricetinae Animals Collagen Antihypertensive Agents |
| Zdroj: | Cardiovascular drugs and therapy. 11(4) |
| ISSN: | 0920-3206 |
| Popis: | This study delineates the role of angiotensin II type I (AT1) receptor in the remodeling of Syrian cardiomyopathic hamsters. Twelve cardiomyopathic (T0-2) hamsters received L-158,809 treatment and libitum in their drinking water (27 micrograms/ml) and 9 cardiomyopathic and 9 normal FL-B hamsters received tap water from 1 to 4 months of age. Although pharmacologically effective with regard to complete suppression of the blood pressure response to angiotensin II infusion, L-158,809 did not diminish the progression or severity of cardiomyopathy. Heart weight/100 g body weight and left ventricular wall thickness adjusted for body weight of both L-158,809 and cardiomyopathic control hamsters did not differ and exceeded those of F1-B controls (p0.05). Myocardial material properties (e.g., stiffness and density) of cardiomyopathic hamsters treated with L-158,809 were not affected. Thus, the progression of fibrosis, calcification, and necrosis in T0-2 cardiomyopathic hamsters was not sensitive to AT1 receptor blockade. |
| Databáze: | OpenAIRE |
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