| Autor: |
Marina, Firmino, Simone N, Weis, Jaques M F, Souza, Bruna R B, Gomes, Alan R, Mól, Márcia R, Mortari, Gloria E P, Souza, Guilherme C, Coca, Thomas C R, Williams, Wagner, Fontes, Carlos André O, Ricart, Marcelo V, de Sousa, Fabiane H, Veiga-Souza |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Journal of proteomics. 187 |
| ISSN: |
1876-7737 |
| Popis: |
Fever is a brain-mediated increase in body temperature mainly during inflammatory or infectious challenges. Although there is considerable data regarding the inflammation pathways involved in fever, metabolic alterations necessary to orchestrate the complex inflammatory response are not totally understood. We performed proteomic analysis of rat hypothalamus using label-free LC-MS/MS in a model of fever induced by lipopolysaccharide (LPS) or prostaglandin EThe evolutionary persistence of fever, despite the elevated cost for maintenance of this response, suggests that elevation in core temperature may represent an interesting strategy for survival. Fever response is achieved through the integrated behavioral, physiological, immunological and biochemical processes that determine the balance between heat generation and elimination. The development of such complex response arouses interest in studying how the cell metabolism responds or even contributes to promote fever. Our results offered comprehensive information about fever responses, including metabolic and inflammatory pathways, providing new insights into candidate proteins potentially involved in inflammatory signaling and metabolic changes in the hypothalamus during fever induced by systemic LPS and central PGE |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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