Secretory leukocyte protease inhibitor blocks infectivity of primary monocytes and mononuclear cells with both monocytotropic and lymphocytotropic strains of human immunodeficiency virus type I

Autor:	D C, Shugars, D L, Sauls, J B, Weinberg
Rok vydání:	1997
Předmět:	Serine Proteinase Inhibitors Virulence HIV-1 Leukocytes Mononuclear Proteinase Inhibitory Proteins Secretory Humans Proteins HIV Infections Secretory Leukocyte Peptidase Inhibitor Salivary Proteins and Peptides Antiviral Agents Monocytes
Zdroj:	Oral diseases. 3
ISSN:	1354-523X
Popis:	Saliva contains factors that inhibit infection with the human immunodeficiency virus type 1 (HIV-1) in vitro. One of these factors was recently identified as secretory leukocyte protease inhibitor (SLPI), a salivary protein which blocked HIV-1 infectivity of monocytes and primary T cells at physiologic concentrations (J Clin Invest 1995; 96: 456). Here, we confirm and extend the original report by demonstrating that SLPI protects primary monocytes and peripheral blood mononuclear cells against infection with HIV-1 Ba-L, IIIB and NL4-3. Thus, SLPI may provide a natural barrier against oral transmission of HIV-1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d04e844cf13d3e495802a15f002f2dd2 https://pubmed.ncbi.nlm.nih.gov/9456661 Zobrazit plný text záznamu Plný text