[Treatment of severe hemophagocytic syndrome associated with visceral leishmaniasis]
| Autor: | J, Bouguila, I, Chabchoub, Y, Moncef, A, Mlika, F, Saghrouni, L, Boughamoura, A S, Essoussi |
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| Jazyk: | francouzština |
| Rok vydání: | 2009 |
| Předmět: |
Leishmania
Meglumine Antimoniate Antiprotozoal Agents Immunoglobulins Infant Antineoplastic Agents Phytogenic Lymphohistiocytosis Hemophagocytic Fatal Outcome Meglumine Treatment Outcome Organometallic Compounds Animals Humans Leishmaniasis Visceral Drug Therapy Combination Glucocorticoids Etoposide |
| Zdroj: | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 17(11) |
| ISSN: | 1769-664X |
| Popis: | The association of hemophagocytic syndrome (HS) and visceral leishmaniasis is a frequent disorder during infancy in endemic areas such as Tunisia. The range of severity of HS secondary to visceral leishmaniasis includes both pure biological forms that resolve with antimicrobial therapy and life-threatening emergencies that require specific treatment. We describe 2 cases of severe HS secondary to visceral leishmaniasis. The diagnosis of HS was based on the HLH-2004 diagnostic criteria. Therapy involved pentavalent antimonial (Glucantime) in both cases. The combination of corticosteroids with immunoglobulins, used in the 1st case, but introduced late, led to an unfavorable course and death. In the 2nd case, the specific treatment of HS was based on immunochemotherapy including etoposide and corticosteroids. Progression was favorable with a follow-up of 24 months. Etoposide containing therapeutic regimens can be proposed in severe forms of HS associated with visceral leishmaniasis. |
| Databáze: | OpenAIRE |
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