Interleukin-2 induced immune effects in human immunodeficiency virus-infected patients receiving intermittent interleukin-2 immunotherapy
| Autor: | J A, Kovacs, S, Vogel, J A, Metcalf, M, Baseler, R, Stevens, J, Adelsberger, R, Lempicki, R L, Hengel, I, Sereti, L, Lambert, R L, Dewar, R T, Davey, R E, Walker, J, Falloon, M A, Polis, H, Masur, H C, Lane |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Membrane Glycoproteins Time Factors CD4-CD8 Ratio HIV Infections Receptors Interleukin-2 HLA-DR Antigens Flow Cytometry Lymphocyte Activation ADP-ribosyl Cyclase 1 Antigens Differentiation Lymphocyte Subsets NAD+ Nucleosidase Antigens CD Humans Interleukin-2 Immunotherapy Tachyphylaxis ADP-ribosyl Cyclase Immunologic Memory Cell Division |
| Zdroj: | European journal of immunology. 31(5) |
| ISSN: | 0014-2980 |
| Popis: | To characterize the immunological effects of intermittent IL-2 therapy, which leads to selective increases in CD4+ T lymphocytes in HIV-infected patients, 11 patients underwent extensive immunological evaluation. While IL-2 induced changes in both CD4+ and CD8+ cell number acutely, only CD4+ cells showed sustained increases following discontinuation of IL-2. Transient increases in expression of the activation markers CD38 and HLA-DR were seen on both CD4+ and CD8+ cells, but CD25 (a chain of the IL-2 receptor) increased exclusively on CD4+ cells. This increase in CD25 expression was sustained for months following discontinuation of IL-2, and was seen in naive as well as memory cells. IL-2 induced cell proliferation, but tachyphylaxis to these proliferative effects developed after 1 week despite continued IL-2 administration. It thus appears that sustained CD25 expression selectively on CD4+ cells is a critical component of the immunological response to IL-2, and that intermittent administration of IL-2 is necessary to overcome the tachyphylaxis to IL-2-induced proliferation. |
| Databáze: | OpenAIRE |
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