Autor: |
D, Saidi, M, Heyman, O, Kheroua, G, Boudraa, P, Bylsma, R, Kerroucha, A, Chekroun, J A, Maragi, M, Touhami, J F, Desjeux |
Rok vydání: |
1995 |
Předmět: |
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Zdroj: |
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. 318(6) |
ISSN: |
0764-4469 |
Popis: |
Weaning is a transient period of life during which maternal proteins are replaced by foreign proteins. Concomitantly, in early postnatal life, both digestive and immune systems undergo a maturation process. Allergy to cow's milk protein may develop in human infants during weaning, determining digestive, respiratory, cutaneous or systemic symptoms. We studied the intestinal response to bovine milk beta-lactoglobulin (beta-LG) in infants with cow's milk allergy, first during the active phase, and then during the symptom-free stage. During the active phase, transepithelial transport of the beta-LG across the intestinal epithelial layer stimulated the sensitized subepithelial immune cells. This stimulation induced a rise in short-circuit current suggestive of an electrogenic chloride secretion and impaired protein handling by the epithelium. These findings underline the dual role of the epithelial layer in intestinal function: on one hand, it takes an active part in allowing dietary antigens to stimulate the submucosal system, and on the other hand becomes the target for mediators involved in food allergy. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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