Potentiality of a new compound for in vitro differentiation between halophilic and non-halophilic vibrios

Autor:	R, Ray, A K, Das, N K, Dutta, A N, Chakrabarty, B N, Chaudhuri, S, Seth, Sujata G, Dastidar
Rok vydání:	2003
Předmět:	Hydrolysis Pteridines Polysorbates Microbial Sensitivity Tests Sensitivity and Specificity Anti-Bacterial Agents Mice Surface-Active Agents Pyrimidines Anti-Infective Agents Local Animals Gentian Violet Vibrio parahaemolyticus Vibrio cholerae
Zdroj:	Indian journal of experimental biology. 40(2)
ISSN:	0019-5189
Popis:	Sensitivity of 21 halophilic vibrios and 16 clinical isolates of non-halophilic vibrios was determined against a new possible antivibrio agent, a pyrimidine analogue, 4, 6-dimethylpyrimidine -2-thiol (4,6-DMPT). It appeared to be a vibriocidal agent, having a mean MIC and MBC of 32 microg/ml for halophilic strains and 64 microg/ml for non-halophilic strains and an LD50 of 300 mg/Kg body weight of mice. Thus, 4,6-DMPT may help an in vitro distinction between halophilic and non-halophilic vibrios. Sensitivity of these strains was also studied with respect to pteridine, crystal violet and Tween 80 hydrolysis as further markers distinguishing between these 2 groups which could also be differentiated by their growth on TCBS or/and CLED media.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d0223674a3665a8b3bb7ee090d424f88 https://pubmed.ncbi.nlm.nih.gov/12622188 Zobrazit plný text záznamu