| Autor: |
I, Budavári, J, Fodor, S, Dubecz, J, Fürész |
| Rok vydání: |
1983 |
| Předmět: |
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| Zdroj: |
Acta physiologica Hungarica. 61(3) |
| ISSN: |
0231-424X |
| Popis: |
The effects of whole-body X-irradiation with a dose of (7 Gray) were studied on the time course of systemic responses (fever, leukocytosis, serum coeruloplasmin concentration) in turpentine-induced inflammation and on the acute-phase reaction (coeruloplasmin, haptoglobin and seromucoid) produced by various stressful conditions (turpentine-abscess, immobilization, restraint conditions). Results showed that in the irradiated animals the lack of the leukocytic and febrile response to turpentine administration was accompanied by a normal coeruloplasmin response. Therefore, we have concluded to the involvement of more than one mediator in the development of systemic reactions accompanying inflammation. The leukopenia induced by whole-body irradiation could not prevent the development or reduce the magnitude of the acute-phase response in any of the models analysed. This observation appears to make doubtful the exclusive role of leukocytes in the mediation of the acute-phase reaction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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