Age-dependent depressor effect of L-dopa in dogs with inhibition of extracerebral dopa decarboxylase

Autor:	W L, Wilke
Rok vydání:	1983
Předmět:	Male Aging Time Factors Brain Carbidopa Blood Pressure Levodopa Renin-Angiotensin System Dogs Heart Rate Renin Animals Aromatic Amino Acid Decarboxylase Inhibitors Drug Therapy Combination
Zdroj:	Pediatric research. 17(11)
ISSN:	0031-3998
Popis:	The results of this study demonstrate that a carbidopa-L-dopa combination has a greater depressor effect in puppies than in adult dogs. These effects are believed to be due to the action of a metabolite of L-dopa within the CNS. These data should alert clinicians to the possibility that CNS cardiovascular control centers, which utilize catecholamines as neuromediators, may be more responsive to pharmacological stimulation in the young than in the adult.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cfec4b012ac4e48481222a19aa88f006 https://pubmed.ncbi.nlm.nih.gov/6359046 Zobrazit plný text záznamu