| Autor: |
Anie, Naqvi, Michelle L, MacKintosh, Abigail E, Derbyshire, Anna-Maria, Tsakiroglou, Thomas D J, Walker, Rhona J, McVey, James, Bolton, Martin, Fergie, Steven, Bagley, Garry, Ashton, Philip W, Pemberton, Akheel A, Syed, Basil J, Ammori, Richard, Byers, Emma J, Crosbie |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
International journal of obesity (2005). 46(3) |
| ISSN: |
1476-5497 |
| Popis: |
The incidence of endometrial cancer is rising in parallel with the obesity epidemic. Obesity increases endometrial cancer risk and weight loss is protective, but the underlying mechanisms are incompletely understood. We hypothesise that the immune microenvironment may influence susceptibility to malignant transformation in the endometrium. The aim of this study was to measure the impact of obesity and weight loss on the immunological landscape of the endometrium.We conducted a prospective cohort study of women with class III obesity (body mass index, BMI ≥ 40 kg/mForty-three women with matched serum and tissue samples at all three time points were included in the analysis. Their median age and BMI were 44 years and 52 kg/mWeight loss is associated with reduced systemic inflammation and a recruitment of protective immune cell types to the endometrium, supporting the concept that immune surveillance may play a role in endometrial cancer prevention. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink