Hedgehog family member is expressed throughout regenerating and developing limbs
| Autor: | D R, Stark, P B, Gates, J P, Brockes, P, Ferretti |
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| Rok vydání: | 1998 |
| Předmět: |
DNA
Complementary Base Sequence Sequence Homology Amino Acid Molecular Sequence Data Gene Expression Regulation Developmental Proteins Extremities Tretinoin Xenopus Proteins Protein Biosynthesis Notophthalmus viridescens Trans-Activators Animals Humans RNA Regeneration Female Hedgehog Proteins Tissue Distribution Amino Acid Sequence |
| Zdroj: | Developmental dynamics : an official publication of the American Association of Anatomists. 212(3) |
| ISSN: | 1058-8388 |
| Popis: | Members of the hedgehog family have been shown to play a key role in many developmental processes, including limb patterning and chondrogenesis. We have therefore investigated whether members of this family are also expressed during regeneration of the adult urodele limb and are regulated by retinoic acid (RA), since this derivative induces proximodistal duplications in regenerating limbs, and has been shown to regulate sonic hedgehog (shh) in the developing limbs of birds and mammals. We report here that a newt homologue of Xenopus banded hedgehog, called N-bhh, is uniformly expressed by mesenchymal blastemal cells from the initial stages of regeneration and is up-regulated by RA. In addition, we show that N-bhh is uniformly expressed in the early limb bud of the newt embryo. Since bhh has not been detected in developing limbs of higher vertebrates, its expression in developing and regenerating newt limbs may be related to the regenerative capability of urodeles. |
| Databáze: | OpenAIRE |
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