| Autor: |
V D, Sled', V N, Zinich, A B, Kotliar |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Biokhimiia (Moscow, Russia). 54(9) |
| ISSN: |
0320-9725 |
| Popis: |
The mechanism of ubiquinone homologs reduction by different preparations of mitochondrial NADH dehydrogenase: complex I within submitochondrial particles, isolated NADH-ubiquinone oxidoreductase and soluble low molecular weight NADH dehydrogenase, has been investigated. It has been shown that NADH oxidation via the rotenone-insensitive reaction is associated with one-electron reduction of low molecular weight ubiquinone homologs (Q0, Q1, Q2) to semiquinone with subsequent fast oxidation of the latter by atmospheric oxygen to form a superoxide radical. The two-electron ubiquinone reduction to quinol in the rotenone-sensitive reaction is unaccompanied by the semiquinone release from the enzyme active center into the surrounding solution. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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