Autor: |
Kazumi, Kondo, Keizo, Kan, Yoshihisa, Tanada, Masahiko, Bando, Tomoichi, Shinohara, Muneaki, Kurimura, Hidenori, Ogawa, Shigeki, Nakamura, Takahiro, Hirano, Yoshitaka, Yamamura, Masaru, Kido, Toyoki, Mori, Michiaki, Tominaga |
Rok vydání: |
2002 |
Předmět: |
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Zdroj: |
Journal of medicinal chemistry. 45(17) |
ISSN: |
0022-2623 |
Popis: |
The synthesis and evaluation of both the (R)- and (S)-enantioisomers about the 5-position on a tetrahydro-1H-1-benzazepine derivative were described. The absolute configuration of the (R,R)-isomer (10) was determined by X-ray crystallographic analysis. After evaluation of both enantiomers (compounds R-2, S-2) for binding affinity, cAMP accumulation, and an in vivo study using Brattleboro rats, R-2 showed more potent activity as a V(2) receptor agonist than S-2. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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