Hypertension in pregnancy among HIV-infected women in sub-Saharan Africa: prevalence and infant outcomes

Autor: C, Kilewo, U C M, Natchu, A, Young, D, Donnell, E, Brown, J S, Read, U, Sharma, B H, Chi, R, Goldenberg, I, Hoffman, T E, Taha, W W, Fawzi
Rok vydání: 2010
Předmět:
Zdroj: African journal of reproductive health. 13(4)
ISSN: 1118-4841
Popis: This analysis was performed to determine the prevalence of hypertension and association of MAP (mean arterial pressure) with birth outcomes among HIV-infected pregnant women not taking antiretrovirals. HIV-infected pregnant women, enrolled into the HPTN024 trial in Tanzania, Malawi and Zambia were followed up at 26-30, 36 weeks, and delivery. The prevalence of hypertension was1% at both 20-24 weeks and 26-30 weeks and 1.7% by 36 weeks. A 5 mm Hg elevation in MAP increased the risk of stillbirth at 20-24 weeks by 29% (p = 0.001), 32% (p = 0.001) at 26-30 weeks and of low birth weight (LBW) at 36 weeks by 26% (p = 0.001). MAP was not associated with stillbirth at 36 weeks, LBW prior to 36 weeks, preterm birth, neonatal mortality or the risk of maternal to child transmission (MTCT) of HIV.
Databáze: OpenAIRE