Mesoionic pyrido[1,2-a]pyrimidinones: Discovery of dicloromezotiaz as a lepidoptera insecticide acting on nicotinic acetylcholine receptors

Autor:	Wenming, Zhang, Caleb W, Holyoke, James, Barry, Daniel, Cordova, Robert M, Leighty, My-Hanh T, Tong, Kenneth A, Hughes, George P, Lahm, Thomas F, Pahutski, Ming, Xu, Twyla A, Briddell, Stephen F, McCann, Yewande T, Henry, Yuzhong, Chen
Rok vydání:	2016
Předmět:	Lepidoptera Insecticides Structure-Activity Relationship Animals Pyrimidinones Receptors Nicotinic Protein Binding
Zdroj:	Bioorganicmedicinal chemistry letters. 27(4)
ISSN:	1464-3405
Popis:	A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species. In this communication, we report the part of the optimization program that led to the identification of dicloromezotiaz as a potent insecticide to control a broad range of lepidoptera. Our efforts in discovery, synthesis, structure-activity relationship elucidation, and biological activity evaluation are also presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cf7871824912254694ab2b422bbeb2c0 https://pubmed.ncbi.nlm.nih.gov/28087271 Zobrazit plný text záznamu Full Text from ScienceDirect