| Autor: |
P, Christopoulos, M, Kirchner, J, Roeper, F, Saalfeld, M, Janning, F, Bozorgmehr, N, Magios, D, Kazdal, A L, Volckmar, L M, Brückner, T, Bochtler, M, Kriegsmann, V, Endris, R, Penzel, K, Kriegsmann, M, Eichhorn, F J F, Herth, C P, Heussel, R A, El Shafie, M A, Schneider, T, Muley, M, Meister, M, Faehling, J R, Fischer, L, Heukamp, P, Schirmacher, H, Bischoff, M, Wermke, S, Loges, F, Griesinger, A, Stenzinger, M, Thomas |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Lung cancer (Amsterdam, Netherlands). 148 |
| ISSN: |
1872-8332 |
| Popis: |
Panel-based next-generation sequencing (NGS) is increasingly used for the diagnosis of EGFR-mutated non-small-cell lung cancer (NSCLC) and could improve risk assessment in combination with clinical parameters.To this end, we retrospectively analyzed the outcome of 400 tyrosine kinase inhibitor (TKI)-treated EGFREGFR alterations other than exon 19 deletions (non-del19), TP53 co-mutations, and brain metastases at baseline showed independent associations of similar strengths with progression-free (PFS hazard ratios [HR] 2.1-2.3) and overall survival (OS HR 1.7-2.2), in combination defining patient subgroups with distinct outcome (EGFREGFR variant, TP53 status and brain metastases predict TKI efficacy and survival in EGFR |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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