Contribution of Genotype of DNA Double-strand Break Repair Gene XRCC3, Gender, and Smoking Behavior to Lung Cancer Risk in Taiwan

Autor:	Hung-Jen, Chen, Wen-Shin, Chang, Te-Chun, Hsia, Chia-En, Miao, Wei-Chun, Chen, Shinn-Jye, Liang, An-Chyi, Chen, Jan-Gowth, Chang, Chia-Wen, Tsai, Chin-Mu, Hsu, Chang-Hai, Tsai, Da-Tian, Bau
Rok vydání:	2015
Předmět:	Male Risk Lung Neoplasms Polymorphism Genetic DNA Repair Genotype Smoking Taiwan DNA Middle Aged DNA-Binding Proteins Asian People Risk Factors Case-Control Studies Humans DNA Breaks Double-Stranded Female Genetic Predisposition to Disease Alleles
Zdroj:	Anticancer research. 35(7)
ISSN:	1791-7530
Popis:	The present study evaluated the contribution of genotype of X-ray repair cross-complementing group 3 (XRCC3), age, gender, and smoking to lung cancer risk in Taiwan.A total of 358 patients with lung cancer and 716 controls were investigated for their XRCC3 rs1799794, rs45603942, rs861530, rs3212057, rs1799796, rs861539, rs28903081 genotype, epidemiological and clinical data for association and gene-Iifestyle interactions.The results showed that CT and TT genotypes of XRCC3 rs861539 were associated with increased lung cancer risk (odds ratio=1.81, 95% confidence interval=1.18-2.78; odds ratio=3.43, 95% confidence interval=1.12-10.60, respectively). This polymorphism also influenced lung cancer susceptibility in males and smokers (p=0.0017 and 0.0045, respectively).The T allele of XRCC3 rs861539 contributes to increased risk of lung cancer in Taiwanese, particularly those who are male and smokers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cf19fbdff0dfef766516debeac06f516 https://pubmed.ncbi.nlm.nih.gov/26124335 Zobrazit plný text záznamu