[Effect of concurrent treatment of SSRI on the tyrosine hydroxylase immunoreactivity in the rat locus coeruleus treated with chronic variable stress]
| Autor: | Sachiko, Fujii, Mikio, Asakura, Shigeto, Kanai, Daisuke, Tanaka, Takuji, Hishinumai, Hideaki, Nagashima |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Serotonin Time Factors Tyrosine 3-Monooxygenase Corticotropin-Releasing Hormone Antidepressive Agents Tricyclic Immunohistochemistry Rats Disease Models Animal Norepinephrine Fluvoxamine Chronic Disease Clomipramine Animals Locus Coeruleus Rats Wistar Selective Serotonin Reuptake Inhibitors Stress Psychological |
| Zdroj: | Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. 24(1) |
| ISSN: | 1340-2544 |
| Popis: | Locus coeruleus (LC) is the major component of noradrenergic neurons in the brain. corticotropine-releasing hormone (CRH) and norepinephrine (NE) are suggested to play significant roles in the pathophysiology of depression, although the involvement of the serotonergic system in the CRH-NE systems is not elucidated. Chronic inescapable and unpredictable stress can result in a sustained dysregulation of both of CRH and NE systems. In the present study we have investigated the TH immunoreactivity in the LC by immunohistochemical staining in rats treated with chronic variable stress (CVS) and concurrent administration with clomipramine or fluvoxamine. There was a significant decrease in TH levels 24 h after the last stressor of CVS, followed by a further decrease in that of 72 h later, whereas a marked increase was observed in TH levels immediately after the last stress of CVS 13 d. Concurrent clomipramine and fluvoxamine treatment prevented the sensitization of TH reactivity and the delayed decrease until 72 h later. These data suggest that an increase in serotonin availability would contribute to the normalization of both hypoactivity and sensitization of LC-NE neurons modified under "chronically stressful" situations. |
| Databáze: | OpenAIRE |
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