Sorafenib Maintenance After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With

Autor: Andreas, Burchert, Gesine, Bug, Lea V, Fritz, Jürgen, Finke, Matthias, Stelljes, Christoph, Röllig, Ellen, Wollmer, Ralph, Wäsch, Martin, Bornhäuser, Tobias, Berg, Fabian, Lang, Gerhard, Ehninger, Hubert, Serve, Robert, Zeiser, Eva-Maria, Wagner, Nicolaus, Kröger, Christine, Wolschke, Michael, Schleuning, Katharina S, Götze, Christoph, Schmid, Martina, Crysandt, Eva, Eßeling, Dominik, Wolf, Ying, Wang, Alexandra, Böhm, Christian, Thiede, Torsten, Haferlach, Christian, Michel, Wolfgang, Bethge, Thomas, Wündisch, Christian, Brandts, Susanne, Harnisch, Michael, Wittenberg, Heinz-Gert, Hoeffkes, Susanne, Rospleszcz, Alexander, Burchardt, Andreas, Neubauer, Markus, Brugger, Konstantin, Strauch, Carmen, Schade-Brittinger, Stephan K, Metzelder
Rok vydání: 2020
Předmět:
Zdroj: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 38(26)
ISSN: 1527-7755
Popis: Despite undergoing allogeneic hematopoietic stem cell transplantation (HCT), patients with acute myeloid leukemia (AML) with internal tandem duplication mutation in theIn a randomized, placebo-controlled, double-blind phase II trial (SORMAIN; German Clinical Trials Register: DRKS00000591), 83 adult patients withWith a median follow-up of 41.8 months, the hazard ratio (HR) for relapse or death in the sorafenib group versus placebo group was 0.39 (95% CI, 0.18 to 0.85; log-rankSorafenib maintenance therapy reduces the risk of relapse and death after HCT for
Databáze: OpenAIRE