Evaluation of the TOPKAT system for predicting the carcinogenicity of chemicals

Autor:	M J, Prival
Rok vydání:	2001
Předmět:	Male Fluorocarbons Molecular Structure Carcinogenicity Tests Neoplasms Experimental Phenolphthalein Hydroquinones Nitroparaffins Rats Mice Sex Factors Species Specificity Chloroprene Predictive Value of Tests Benzene Derivatives Carcinogens Animals Female Enzyme Inhibitors Methane
Zdroj:	Environmental and molecular mutagenesis. 37(1)
ISSN:	0893-6692
Popis:	The TOPKAT computer-based system for predicting chemical carcinogens was evaluated by determining its ability to predict the carcinogenicity of chemicals tested by the National Toxicology Program. TOPKAT was not effective in identifying potential rodent carcinogens and noncarcinogens in the data set analyzed. The chemicals in the TOPKAT database of known carcinogens and noncarcinogens that the software identifies as most "similar" to unknown chemicals are illustrated using six examples. These "similar" chemicals generally bear no apparent relationship to the chemical of interest with regard to metabolism or potential mechanism of carcinogenicity. Environ. Mol. Mutagen. 37:55-69, 2001 Published 2001 Wiley-Liss, Inc.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cef45499ea0c9c2d6bfb562e98a979ac https://pubmed.ncbi.nlm.nih.gov/11170242 Zobrazit plný text záznamu Plný text