| Autor: |
B, Wiadrowska, J K, Ludwicki, D, Palut |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Roczniki Panstwowego Zakladu Higieny. 43(3-4) |
| ISSN: |
0035-7715 |
| Popis: |
The effect of simultaneous administration of N-diethylnitrosamine (NDEA) and Nuarimol on the activity of gamma-GTPase, G-6-Pase ans APase in the liver and serum of Wistar rats was investigated in the 2-weeks experiment. The two-stage hepato-cancerogenesis model was used with NDEA as initiating agent. The possible promoting potential of Nuarimol (DDT analogue) was checked in this experiment. gamma-GTPase and G-6-Pase activities were measured by biochemical and histochemical methods and AP-ase activity was measured by a biochemical method only. The occurrence of gamma-GTPase positive foci found by histochemical methods was partly confirmed by colorimetric methods. This suggest the need for further examination of this enzyme in conditions of prolonged exposure to Nuarimol. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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