Treatment, comorbidity and survival in stage III laryngeal cancer
| Autor: | Katie L, Connor, Samuel, Pattle, Gillian R, Kerr, Elizabeth, Junor |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Databases Factual Laryngectomy Comorbidity Kaplan-Meier Estimate Risk Assessment Disease-Free Survival Cause of Death Humans Neoplasm Invasiveness Laryngeal Neoplasms Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Aged 80 and over Chemoradiotherapy Middle Aged Prognosis Combined Modality Therapy Survival Rate Treatment Outcome Scotland Carcinoma Squamous Cell Female Radiotherapy Adjuvant |
| Zdroj: | Headneck. 37(5) |
| ISSN: | 1097-0347 |
| Popis: | The purpose of this study was for us to identify factors associated with survival and laryngeal function in a contemporary, population-based study of stage III laryngeal carcinoma.Patients presenting to a tertiary center with stage III laryngeal carcinoma between 1999 and 2010 were included in the study. Kaplan-Meier and Cox proportional hazards analyses were utilized.Of 137 patients receiving either surgery ± adjuvant therapy (SURG±Adj = 24.1%), chemoradiotherapy (CRT = 32.8%), or radiotherapy alone (RT = 36.5%), 5-year cause-specific survival (5-year CSS) was 81.0% and 2-year local relapse rate was 27.5%. RT had higher recurrence (p.01), lower 5-year CSS (90.8% vs 87.8% vs 68.9%/SURG±Adj vs CRT vs RT/p = .0026) and lower overall survival (p = .001). Adjusting for excess of severe comorbidity in the RT group, there was no difference in 5-year CSS between treatment modality.SURG±Adj and CRT had similar survival. Severe comorbidity was associated with selection bias to RT and reduced 5-year CSS. Comorbidity is a key prognostic variable and should be considered in the interpretation of treatment outcomes. |
| Databáze: | OpenAIRE |
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