[The impact of diabetes mellitus and insulin interference on cortical SCF/KIT of mice]

Autor: Luo, Yun, Niu, Feng-nan, Zhu, Wen-jing, Xu, Yun
Rok vydání: 2010
Předmět:
Zdroj: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 26(1)
ISSN: 1000-6834
Popis: To investigate the expression of cortical SCF/KIT system at different blood glucose level in mice.27 male C57 mice were randomly divided into control group, diabetes group, and diabetes plus insulin group. The diabetic mice were induced by streptozotocin. Western-blot and double-immunofluorescence histochemistry were used to detect the expression of SCF and KIT.Both methods indicate that the level of S-SCF and M-SCF were decreased significantly in the diabetes group, and this trend can be reversed effectively when the insulin was utilized.The decline of SCF might be one of underlying mechanisms of diabetic encephalopathy.
Databáze: OpenAIRE