| Autor: |
Pourfathi, Mehrdad, Xin, Yi, Kadlecek, Stephen J., Cereda, Maurizio F., Profka, Harrilla, Hamedani, Hooman, Siddiqui, Sarmad M., Ruppert, Kai, Drachman, Nicholas A., Rajaei, Jennia N., Rizi, Rahim R. |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Popis: |
To investigate pulmonary metabolic alterations during progression of acute lung injury.Using hyperpolarized [1-The mean lactate-to-pyruvate ratio of the injured-1 cohort was 0.15 ± 0.02 and 0.15 ± 0.03 at baseline and 1 h after the injury, and significantly increased from the baseline value 3 h after the injury to 0.23 ± 0.02 (P = 0.002). The mean lactate-to-pyruvate ratio of the injured-2 cohort decreased from 0.14 ± 0.03 at baseline to 0.08 ± 0.02 1 h after the injury and further decreased to 0.07 ± 0.02 (P = 0.08) 3 h after injury. No significant change was observed in the control group. Compliance in both injured groups decreased significantly after the injury (P 0.01).Our findings suggest that in severe cases of lung injury, edema and hyperperfusion in the injured lung tissue may complicate interpretation of the pulmonary lactate-to-pyruvate ratio as a marker of inflammation. However, combining the lactate-to-pyruvate ratio with pulmonary compliance provides more insight into the progression of the injury and its severity. Magn Reson Med 78:2106-2115, 2017. © 2017 International Society for Magnetic Resonance in Medicine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
