| Autor: |
J C, Sisson, B, Shapiro, R J, Hutchinson, K R, Zasadny, S, Mallette, E E, Mudgett, D M, Wieland |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Journal of nuclear biology and medicine (Turin, Italy : 1991). 35(4) |
| ISSN: |
0368-3249 |
| Popis: |
To find a treatment that may be effective against micrometastases of advanced, stage III or IV neuroblastoma, [125I]metaiodobenzylguanidine (125I-MIBG) was used in a phase I toxicity trial. In seven patients, thrombocytopenia was encountered with absorbed whole body doses of 85-135 rad from 125I-MIBG, but the dosimetry was imprecise in predicting bone marrow injury. Three patients survived for over one year, results that may indicate efficacy of 125I-MIBG therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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