| Autor: |
Peter, Fischer, Alfio, Comis, Margaret, Tyler, Merlin, Howden |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Indian journal of biochemistrybiophysics. 44(3) |
| ISSN: |
0301-1208 |
| Popis: |
The objective of this study was to determine whether certain retro-inverso peptides have the potential to act as synthetic vaccines in mice, when immunized by injection or orally. Immunization of mice parenterally with conjugates of three such retro-inverso peptides and orally with the unconjugated peptides elicited generally high titres of anti-peptide antibodies. Antibodies against the same three peptides cross-reacted by binding strongly in ELISA to the native peptides and vice versa, regardless of the mode of immunization. Antibodies against a retro-inverso diphtheria peptide also reacted strongly with diphtheria toxin. Seven of 8 mice, immunized by injection of the conjugate of a retro-inverso derivative of robustoxin [a lethal spider (Atrax robustus) venom toxin] were protected from challenge involving injection with twice the minimum lethal dose of A. robustus venom containing the toxin. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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