Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations

Autor:	Charlotte R, Bell, Victoria S, Pelly, Agrin, Moeini, Shih-Chieh, Chiang, Eimear, Flanagan, Christian P, Bromley, Christopher, Clark, Charles H, Earnshaw, Maria A, Koufaki, Eduardo, Bonavita, Santiago, Zelenay
Rok vydání:	2021
Předmět:	Cyclooxygenase 2 Neoplasms Antineoplastic Agents Immunotherapy Dinoprostone Up-Regulation
Zdroj:	Nature communications. 13(1)
ISSN:	2041-1723
Popis:	Cytotoxic therapies, besides directly inducing cancer cell death, can stimulate immune-dependent tumor growth control or paradoxically accelerate tumor progression. The underlying mechanisms dictating these opposing outcomes are poorly defined. Here, we show that cytotoxic therapy acutely upregulates cyclooxygenase (COX)-2 expression and prostaglandin E
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ce014396e370dc3ff507090ddd1db8cf https://pubmed.ncbi.nlm.nih.gov/36120509 Zobrazit plný text záznamu Full text from SpringerLink